Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid
Identifieur interne : 001D55 ( Main/Exploration ); précédent : 001D54; suivant : 001D56Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid
Auteurs : R. Dörries [Allemagne] ; R. Watanabe [Allemagne] ; H. Wege [Allemagne] ; V. Ter Meulen [Allemagne]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1986.
English descriptors
- Teeft :
- Acta neuropathol, Animal sample blot, Antibody, Antibody indices, Antigen specificity, Antiviral activity, Antiviral antibodies, Black arrows, Causative agent, Cell clones, Cerebrospinal, Cerebrospinal fluid, Clinical disease, Clonal distribution, Coronavirus, Crystal violet, Demyelinating, Demyelinating disease, Demyelinating diseases, Demyelinating encephalomyelitis, Diseased animals, Encephalomyelitis, Filter area, Glial cells, Immune, Immune response, Immunoblot, Immunoblot analysis, Immunoblot technique, Immunoglobulin, Inflammatory demyelinating lesions, Inoculation, Intrathecal, Intrathecal synthesis, Keyhole limpet hemocyanine, Lewis rats, Meulen, Multiple sclerosis, Mumps meningitis, Murine coronavirus, Nervous system, Neurol, Nitrocellulose filter, Normal range, Oligoclonal, Oligoclonal pattern, Optical density, Rat, Same animal, Serum samples, Serum specimens, Specific antibody indices, Spinal cord, Subacute, Subacute demyelinating encephalomyelitis, Subacute sclerosing panencephalitis, Vandvik, Viral, Viral antibodies, Viral antigen, Viral antigens, Virus infection, Virus inoculation, Virus strain, Wege.
Abstract
Abstract: The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.
Url:
DOI: 10.1016/0165-5728(86)90026-3
Affiliations:
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Ter Meulen</name><affiliation wicri:level="0"><country wicri:rule="zip">Allemagne</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1986">1986</date><biblScope unit="volume">12</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="131">131</biblScope><biblScope unit="page" to="142">142</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta neuropathol</term><term>Animal sample blot</term><term>Antibody</term><term>Antibody indices</term><term>Antigen specificity</term><term>Antiviral activity</term><term>Antiviral antibodies</term><term>Black arrows</term><term>Causative agent</term><term>Cell clones</term><term>Cerebrospinal</term><term>Cerebrospinal fluid</term><term>Clinical disease</term><term>Clonal distribution</term><term>Coronavirus</term><term>Crystal violet</term><term>Demyelinating</term><term>Demyelinating disease</term><term>Demyelinating diseases</term><term>Demyelinating encephalomyelitis</term><term>Diseased animals</term><term>Encephalomyelitis</term><term>Filter area</term><term>Glial cells</term><term>Immune</term><term>Immune response</term><term>Immunoblot</term><term>Immunoblot analysis</term><term>Immunoblot technique</term><term>Immunoglobulin</term><term>Inflammatory demyelinating lesions</term><term>Inoculation</term><term>Intrathecal</term><term>Intrathecal synthesis</term><term>Keyhole limpet hemocyanine</term><term>Lewis rats</term><term>Meulen</term><term>Multiple sclerosis</term><term>Mumps meningitis</term><term>Murine coronavirus</term><term>Nervous system</term><term>Neurol</term><term>Nitrocellulose filter</term><term>Normal range</term><term>Oligoclonal</term><term>Oligoclonal pattern</term><term>Optical density</term><term>Rat</term><term>Same animal</term><term>Serum samples</term><term>Serum specimens</term><term>Specific antibody indices</term><term>Spinal cord</term><term>Subacute</term><term>Subacute demyelinating encephalomyelitis</term><term>Subacute sclerosing panencephalitis</term><term>Vandvik</term><term>Viral</term><term>Viral antibodies</term><term>Viral antigen</term><term>Viral antigens</term><term>Virus infection</term><term>Virus inoculation</term><term>Virus strain</term><term>Wege</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Dorries, R" sort="Dorries, R" uniqKey="Dorries R" first="R." last="Dörries">R. Dörries</name></noRegion><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R." last="Watanabe">R. Watanabe</name><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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